Could a combination of broccoli sprouts and green tea offer protection against breast cancer — and transform hard-to-treat breast tumors into a type that responds to medication?
A series of studies in the lab of UAB biologist Trygve Tollefsbol, Ph.D., D.O., have generated encouraging findings. Tollefsbol, who is also a senior scientist in the UAB Comprehensive Cancer Center, has shown that mice given sprouts in their chow and green tea polyphenols in their water are protected against tumor development. Intriguingly, he has also shown in animal studies that the combination can change estrogen receptor-negative (ER-) tumors, which have few treatment options, into estrogen receptor-positive (ER+) tumors, which can be treated with the anti-estrogen drug tamoxifen.
Now, Tollefsbol has received a $1.5-million, five-year grant from the National Institutes of Health to pinpoint the molecular mechanisms behind these effects. "We already have a lot of preliminary data showing that this combination works," Tollefsbol says. "The grant will allow us to extend that research and explore the effects genome-wide."